Drug Lab

Multidisciplinary team focused on understanding substance use disorders

Research in the Drug Lab focuses on mechanism-based determinants and modification of addictive behaviors. Our lab uses rigorous human experimental approaches, medications and pharmacological probes, multi-modal magnetic resonance imaging, neuromodulation, and behavioral, subjective and physiological endpoints to investigate hypothesized relationships.

There are several ongoing projects in the lab. Students at various levels of training (e.g. postdoctoral, graduate, medical, undergraduate) are routinely involved in our research and obtain mentored scientific experiences. Beyond these studies, we are actively engaged in several other collaborative projects with other labs at Wayne State University and across the country.

Manuscripts under review and in preparation

Bauer AR, Moses TEH, Lundahl LH, Greenwald MK (in preparation) Deep behavioral phenotyping of persons in treatment for opioid use disorder: concordance with the Addictions Neuroclinical Assessment framework.

Bauer AR, Greenwald MK (in preparation) Algorithm for personally-tailored, extended-release morphine stabilization doses in persons with opioid use disorder: efficacy evaluation.

Bavishi P, Harsono D, Mistler C, Ledgerwood DM, Bold K, Sigel K, Weiss J, Yager JE, Bernstein, SL, Edelman, EJ (under review) Perspectives on a clinical pharmacist-delivered contingency management to promote smoking abstinence among individuals with HIV: a qualitative study. AIDS and Behavior.

Bernstein SL, Yager JE, Sigel, KM, Porter E, Do T, Vuernick E, Fiellin DA, Bold KW, Ledgerwood DM, Edelman EJ (in press) Discordance between insurance coverage of antiretroviral medications and smoking cessation medications among individuals with HIV who smoke: a case series. Journal of Addiction Medicine.

Czao A, Potenza MN, Hodgins DC, Yu SM, Wu AMS, Jimenez-Murcia S., Bowden-Jones H, King D, Billieux J, Bothe B, Gambling Research Priority Setting Consortium (DM Ledgerwood is a member), Demetrovics Z (in preparation) Research priorities in gambling: findings of a large-scale expert study.

Eisman AB, Moore EWG, Paulateer MJ, Ledgerwood DM, Smith SN, Kilbourn AM (under review) Augmenting a low-level implementation strategy to address co-occurring cigarette use and mental health disorders: outcomes from the Adaptive Implementation of Effective Programs Trial (ADEPT). Journal of Behavioral Health Services and Research.

Eisman AB, Palinkas LA, Brown S, Lundahl LH, Kilbourne AM (revise/resubmit) Key implementation determinants of an evidence-based universal drug use prevention intervention: a mixed methods study. Implementation Science.

Fodor M, Lundahl LH (in preparation) Sex differences in subjective and physiological responses to oral THC in cannabis-dependent volunteers.

Greenwald MK, Arfken CL, Winston J (under review) A randomized, sham-controlled clinical trial to evaluate the NET Device™ for reducing withdrawal symptom severity during opioid discontinuation. Frontiers in Psychiatry.

Greenwald MK, Arfken CL, Winston J (in preparation) Efficacy of the NET Device™ in promoting outpatient opioid abstinence without use of medications for opioid use disorder.

Greenwald MK, Bauer AR, Moses TEH, Burghardt P (in preparation) Development of an experimental model for testing anti-stress medications in opioid use disorder: pilot test of buprenorphine/naloxone.

Greenwald MK, Hull JT, Maldonado-Cruz Z, Nair G, Garcia-Olivares J, Koch J, Maletic V, Nasser A (in preparation) A comprehensive review of the abuse potential of viloxazine extended-release capsules (Qelbree™): a nonstimulant medication for the treatment of attention-deficit/hyperactivity disorder. Drug and Alcohol Dependence.

Greenwald MK, Kalaj A, Burmeister M, Roehrs TA (in preparation) Predictors of heroin-use circadian pattern: demographics, non-opioid substance use, and CLOCK genetic variation.

Greenwald MK, Mascarin AT, Burstein WB, Grasser L (in preparation) Same-day and consecutive-day cocaine, alcohol, and cannabis polysubstance use in primary cocaine users: a novel timeline followback-based analytic approach.

Greenwald MK, Moses TEH, Lundahl LH, Burmeister M (in preparation) Kappa opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users.

Greenwald MK, Roehrs TA, Ghosh S (in preparation) A placebo-controlled, randomized trial to evaluate dual-orexin antagonism for improving sleep efficiency and opioid abstinence in patients with opioid use disorder.

Hansson J, Bauer S, Thomas H, Lundahl LH, Ledgerwood DM (under review) Tobacco use and sleep: analysis of the Population Assessment of Tobacco and Health (PATH) dataset. Drug and Alcohol Dependence.

Heule M, Kouri N, Lundahl LH, Greenwald MK (in preparation) PTSD diagnosis increases the mediating effect of distress tolerance on pain interference and opioid misuse.

Huailei J, Roy P, Guo Y, Muzik O, Woodcock EA (in revision) Automated radiosynthesis of [11C]CPPC for imaging neuroimmune state in humans.

Jhand A, Greenwald MK (in preparation) Magnitude of money alternative disrupts initial choice, repetitive choices, latency of choices, and progressive-ratio effort for hydromorphone in regular heroin users.

Kouri N, Greenwald MK (in preparation) Yohimbine stress moderates the relationship between opioid-craving and seeking behavior.

Kouri N, Najavits LM, Ledgerwood DM (under review) Posttraumatic stress symptoms and gambling disorder severity: a Bayesian model averaging approach. Journal of Gambling Studies.

Ledgerwood DM, Bedi DK, Bedi MK, Cannoy C, Prakash K, Lundahl LH (in preparation) Gender and age differences in reasons for electronic cigarette use.

Ledgerwood DM, Cannoy C, Excell S, Mehmood Y, Lundahl LH (in preparation) Health impact of Covid 19 among cigarette smokers, e-cigarette users and non-smokers.

Ledgerwood DM, Stott M, Quesada S, Sontag M, Beck RM, McDonell MG, Johnson D, DePhilippis D, Donnelly S, Hartzler B, Nauts T, Novak MD, Peck JA, Rash CJ (revise/resubmit) Implementing contingency management into rural recovery housing: recommendations of a professional advisory panel. American Journal on Drug and Alcohol Abuse.

Li J, Ledgerwood DM (in preparation) Food addiction, impulsivity and concurrent substance use in individuals meeting overweight or obese criteria.

Lundahl LH, Cannoy C, Arfken CL, Cohn J, Greenwald MK (in preparation) Cannabis use frequency is associated with viral load suppression and biobehavioral outcomes among persons living with HIV.

Lundahl LH, Greenwald MK (in preparation) Smoked cannabidiol attenuates cardiovascular but not subjective or reinforcing effects of smoked THC.

Lundahl, LH, Greenwald MK (in preparation) N-acetylcysteine does not reduce cannabis seeking behavior in a laboratory choice task.

Madden EF, Qeadan F, Fabris F, Cohn J, Barbeau W, Greenwald MK (under review) Reducing stigma in primary care toward people who use drugs: the promise and limits of stigma training. Journal of Substance Use and Addiction Treatment.

Mascarin AT, Burmeister M, Greenwald MK (under review) Recent cocaine-use pattern and problem severity differ by corticotropin-releasing hormone receptor 1 (CRHR1) genotype.

Mascarin AT, Mac AM, Kallakuri S, Greenwald MK, Perrine SA (under review) Food restriction sex-dependently impacts cocaine self-administration and cocaine-seeking in rats. Drug and Alcohol Dependence.

Moses TEH, Chammaa M, Moreno J, Ramos R, Waineo E, Greenwald MK (in preparation) Opioid overdose prevention and response training for first year medical students: does the training provide a benefit beyond the traditional curriculum?

Nahmoud I, Perrine S, Conti A, Woodcock EA (in preparation) Kynurenine pathway dysfunction in traumatic brain injury.

O’Mara EC, Tamimi RN, Diwadkar VA, Lundahl LH, Khatib D, Marusak H, Greenwald MK, Woodcock EA (in preparation) Cues augment working memory proficiency in smokers: preliminary evidence that attentional bias enhances executive function.

Poland CA, Alan J, Malinowski R, Greenwald MK (in preparation) Meeting the demand for care and reducing stigma: development of a novel addiction medicine elective.

Roy P, Guo Y, Muzik O, Woodcock EA, Jiang H (under review) Fully automated radiosynthesis of [18F]FCPPC for imaging microglia with PET. Journal of Labelled Compounds and Radiopharmaceuticals.

Sogbesan A, Lister JL, Lundahl LH, Greenwald MK, Woodcock EA (in preparation) Emergency department utilization among individuals with opioid use disorder.

Starnes W, Kopetz C, Ledgerwood DM (under review) The experience of decisional conflict among intermittent and daily smokers. Psychology of Addictive Behaviors.

Struble C, Roehrs TA, Ellis J, Lundahl LH (under review) Cannabis normalizes sleep efficiency in volunteers with cannabis use disorders. Cannabis and Cannabinoid Research.

Tamimi RN, Zundel C, Ely S, Shampine M, O’Mara EC, Gowatch L, Bhogal A, Carpenter C, Woodcock EA, Marusak H (in preparation) Artifact mitigation in pediatric fMRI: enhancing data quality through multi-echo data acquisition and preprocessing.

Thomas H, Greenwald MK, Lundahl LH (in preparation) Effects of cannabidiol on subjective indices of morphine abuse liability.

Thomas C, Heule M, Lundahl LH, Ledgerwood DM (in preparation) Exploring the intersection of racial trauma, addiction and perspectives on the menthol cigarette prohibition.

Woodcock EA, Angarita GA, Matuskey D, Ropchan J, Nabulsi N, Huang H, Carson RE, Cosgrove KP (in preparation) Elevated neuroimmune signaling in opioid use disorder: an inpatient PET TSPO study.

Woodcock EA, Angarita GA, Matuskey D, Ropchan J, Nabulsi N, Huang H, Hillmer AT, Carson RE, Cosgrove KP (in preparation) Acute opioid administration evokes a neuroimmune response in healthy adults: implications for opioid use disorder.

Woodcock EA, Arshad M, Moses TEH, Diwadkar VA, Greenwald MK (in preparation) Acute stress modulates hippocampal memory and opioid craving in opioid use disorder: a pharmacological dissociation study of noradrenergic vs. cortisol effects.

Woodcock EA, Diwadkar VA, Lundahl LH, Khatib D, Greenwald MK, Stanley JA (in preparation) Smokers exhibit less glutamate modulation in the dorsolateral prefrontal cortex during working memory than non-smokers: an 1H fMRS study.

Woodcock EA, Diwadkar VA, Stanley JA, Tadesse O, Khatib D, Greenwald MK (in preparation) Neural activation during smoking cues among non-treatment-seeking smokers is modulated by acute stress: a pharmaco-imaging study.

Woodcock EA, Greenwald MK, Petriello MK, Lundahl LH, King AM, Muzik O (in preparation) Kynurenine pathway dysfunction in opioid use disorder: evidence from [11C]AMT PET imaging.

2024

Bonomi R, Hillmer AT, Woodcock EA, Angarita GA, Davis MT, Bhatt S, Pietrzak R, Cosgrove KP (in press) Suppressed neuroimmune function in PTSD: evidence from PET imaging. Proceedings of the National Academy of Sciences.

Browning L, Cannoy CN, Moses TEH, Lundahl LH, Ledgerwood DM, Greenwald MK (2024 Apr 13) Attention-deficit/hyperactivity disorder combined subtype exacerbates opioid use disorder consequences: mediation by impulsive phenotypes. Drug and Alcohol Dependence 259: 111292.

Cunningham PB, Naar S, Roberts J, Powell J, Ledgerwood DM, Randall J, Lozano BE, Halliday CA, Madisetti M, Ghosh S (2024) Study protocol for clinical trial of FIT Families multicomponent obesity intervention for African American adolescents and their caregivers: next step from the ORBIT Initiative. BMJ Open 14(2): e074552.

Greenwald MK (in press) Mechanisms, efficacy and safety of cannabinoids for treating chronic pain. In: The Other Side of Cannabis: Impact on Mental and Physical Health (Eds., Balon R, Morreale M). American Psychiatric Association Publishing.

Greenwald MK, Sogbesan T, Moses TEH (2024) Relationship between opioid cross-tolerance during buprenorphine stabilization and return to use during buprenorphine dose tapering. Psychopharmacology 241: 1151-1160.

Greenwald MK, Woodcock EA, Moses TEH, Lundahl LH (2024) Baseline cortisol level modulates stress-induced opioid-seeking behavior. Neurobiology of Stress 33: 100684

Heidbreder C, Greenwald MK, Le Foll B, Skolnick P (2024) Editorial: Discovery, development and implementation of improved options for treating overdose in the synthetic opioid era. Frontiers in Psychiatry 15: 1443304. 

Jiang H, Roy P, Guo Y, Muzik O, Woodcock EA (2024) Automated radiosynthesis of [11C]CPPC for in-human PET imaging applications. American Journal of Nuclear Medicine and Molecular Imaging 14(2): 144.

Ledgerwood DM, Bedi MK, Bedi DK, Cannoy C, Prakash K, Foulon A, Excell S, Lundahl LH (2024) Development and validation of a reasons for electronic cigarette use questionnaire. Experimental and Clinical Psychopharmacology 32(4): 445-452.

Lundahl LH, Ledgerwood DM (in press) The effects of adolescent cannabis use on psychosocial functioning in adulthood. In: The Other Side of Cannabis: Impact on Mental and Physical Health (Eds., Balon R, Morreale M). American Psychiatric Association Publishing.

Ledgerwood DM, Lundahl LH, Cohn J, Greenwald MK, Arfken CL (2024) Prize-based incentives for smoking cessation among people with HIV: a sequential multiple assignment randomized trial (SMART). Nicotine & Tobacco Research. DOI: 10.1093/ntr/ntae243

Ledgerwood DM, Stott MC, Quesada S, et al. (2024 Aug 22) Implementing contingency management into rural recovery housing: recommendations of a professional advisory expert panel. American Journal of Drug and Alcohol Abuse 1-10. DOI: 10.1080/00952990.2024.2387725

Madden EF, Frabis F, Cohn J, Qeadan F, Mann CRC, Greenwald MK (2024) Perceptions of structural and provider-based substance use stigma interventions among primary care professionals. Drug and Alcohol Dependence Reports 12: 100259.

McDonell M, Rash C, Rawson R, Parent S, Heil S, Erath T, …., Ledgerwood DM… et al. (in press) Contingency management for stimulant use disorder. American Journal of Psychiatry.

Moses TEH, Lenz DA, Lundahl LH, Mischel NA, Rabinak C, Greenwald MK (2024) Left ventromedial prefrontal cortex inhibitory rTMS as an anti-stress intervention in opioid use disorder: trial design. Contemporary Clinical Trials Communications. DOI: 10.1016/j.conctc.2024.101414

Najavits LN, Ledgerwood DM, Afifi T (in press) Clinical trial of telehealth-based Seeking Safety for co-occurring gambling disorder and trauma. Journal of Gambling Studies.

Rash CJ, McDonnell M, Erath T, Parent S, Rawson R, Wattenberg S; Contingency Management Signatory Panel** (in press) A call to action: evidence-based contingency management. The American Journal of Psychiatry. (**Dr. Ledgerwood is a panel signatory.)

Sogbesan A, Lenz D, Lister JJ, Lundahl LH, Greenwald MK, Woodcock EA (2024) Mediational pathways among drug use initiation, use-related consequences, and quit attempts. Drug and Alcohol Dependence Reports 11: 100229.

2023

Cannoy C, Bauer S, Prakash K, Excell S, Ghosh S, Lundahl LH, Ledgerwood DM (2003) Response to health warnings on cigarette packs as a predictor of future smoking among current tobacco smokers. Addictive Behaviors 144: 107717.

Carr MM, Ellis JD, Saules KK, Ledgerwood DM (2023) Childhood adversity, addiction severity, and comorbidity among patients receiving opioid use disorder treatment: the role of emotion regulation. Journal of Nervous and Mental Disease 211(2): 150-156.

Dodge NC, Jacobson JL, Lundahl LH, Jacobson SW (2023) Prenatal alcohol exposure and attention-deficit/hyperactivity disorder independently predict greater substance use in young adulthood. Alcohol: Clinical and Experimental Research 47: 1143-1155.

Ellis JD, Lister JJ, Wohl MJA, Greenwald MK, Ledgerwood DM (2023) Exploring potential moderators of depressive symptoms and treatment outcomes among patients with opioid use disorder. Addictive Behaviors 140: 107604.

Evanski J, Zundel CG, Baglot SL, Desai S, Gowatch LC, Ely SL, Sadik N, Lundahl LH, Hill MN, Marusak HA (2023) The first “hit” to the endocannabinoid system? Associations between prenatal cannabis exposure and frontolimbic white matter pathways in children. Biological Psychiatry: Global Open Science 4(1): 11-18.

Faraj M, Dautrich T, Lundahl LH, Marusak HA (2023) Effects of two cannabidiol (CBD) oil products on self-reported stress relief under naturalistic conditions. Medical Cannabis and Cannabinoids 6(1): 138-147.

Grande LA, Cundiff D, Greenwald MK, Murray M, Wright TE, Martin SA (2023) Evidence on buprenorphine dose limits: a review. Journal of Addiction Medicine 17: 509-516.

Greenwald MK, Moses TEH, Lundahl LH, Roehrs TA (2023) Anhedonia modulates benzodiazepine and opioid demand among persons in treatment for opioid use disorder. Frontiers in Psychiatry 14: 1103739.

Greenwald MK, Wiest K, Haight B, Laffont CM, Zhao Y (2023) Examining the benefit of a higher maintenance dose of extended-release buprenorphine in opioid-injecting users treated for opioid use disorder. Harm Reduction Journal 20: 173.

Heidbreder C, Fudala PJ, Greenwald MK (2023) History of the discovery, development, and FDA-approval of buprenorphine medications for the treatment of opioid use disorder. Drug and Alcohol Dependence Reports 6: 100133.

Faraj MM, Evanski J, Zundel C, Peters C, Brummelte S, Lundahl LH, Marusak H (2023) Impact of prenatal cannabis exposure on functional connectivity of the salience network in children. Journal of Neuroscience Research 101: 162-171.

Moses TEH, Gray E, Mischel N, Greenwald MK (2023) Effects of neuromodulation on cognitive and emotional responses to psychosocial stressors in healthy humans. Neurobiology of Stress 22: 100515.

Moses TEH, Waineo E, Levine D, Greenwald MK (2023) Optimizing buprenorphine training during undergraduate medical education: medical student feedback and attitudes. The American Journal on Addictions 32: 376-384.

Najavits LM, Ledgerwood DM, Afifi TO (2023) A randomized controlled trial for gambling disorder and PTSD: Seeking Safety and CBT. Journal of Gambling Studies 39(4): 1865-1884.

Ryan-Pettes SR, Morrison M, Randall J, Halliday C, Ledgerwood DM, Cunningham PB (2023) Juvenile probation officer perception of contingency management to target caregiver engagement and training outcomes. Journal of Offender Rehabilitation 62(5): 315-335.

Woodcock EA, Greenwald MK, Chen I, Feng D, Cohn JA, Lundahl LH (2023) HIV chronicity as a predictor of hippocampal memory deficits in daily cannabis users living with HIV. Drug and Alcohol Dependence Reports 9: 100189.

2022

Azar P, Wong JSH, Mathew N, Vogel M, Perrone J, Herring AA, Krausz RM, Montaner JSG, Greenwald MK, Maharaj AR (2022) 48-hour induction of transdermal buprenorphine to sublingual buprenorphine/naloxone: the IPPAS method. Journal of Addiction Medicine. DOI: 10.1097/ADM.0000000000001072

Azar P, Mathew N, Mahal D, Wong JSH, Westenberg JN, Schütz CG, Greenwald MK (2022) Developing a rapid transfer from opioid full agonist to buprenorphine: ‘ultrarapid micro-dosing’ proof of concept. Journal of Psychoactive Drugs. DOI: 10.1080/02791072.2022.2039814

Bedi DK, Bedi MK, Ledgerwood DM (2022) Gender differences in reasons for using electronic cigarettes: a systematic review. Nicotine and Tobacco Research 24(9): 1355-1362.

Bold KW, Deng Y, Dziura J, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL, Edelman EJ (2022) Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multi-site cross-sectional survey. Translational and Behavioral Medicine 12(6): 726-733.

Clark L, Billieux J, Ledgerwood DM (2022) Introduction to the special issue “20 years of the pathways model: understanding disordered gambling and other behavioural addictions”. International Gambling Studies 22: 183-187.

Eisman AB, Palinkas LA, Koffkey C, Herrenkohl TI, Abbasi U, Fridline J, Lundahl LH, Kilbourne AM (2022) Michigan Model for Health Learning to Enhance and Adapt for Prevention (Mi-LEAP): protocol of a pilot randomized trial comparing enhanced replicating effective programs versus standard implementation to deliver an evidence-based drug use prevention curriculum. Pilot and Feasibility Studies 8: 204. DOI 10.1186/s40814-022-01145-6

Ellis JD, Struble C, Fodor M, Cairncross M, Lundahl LH, Ledgerwood DM (2022) Contingency management for chronic health conditions: a meta-analysis of randomized controlled trials. Behavior Research and Therapy 136: 103781.

Excell S, Cannoy CN, Bedi DK, Bedi MK, Mehmood Y, Lundahl LH, Ledgerwood DM (2022) Gambling disorder subtypes: an updated systematic review. International Gambling Studies 22: 188-210.

Foster B, Ledgerwood DM, Struble C, Fodor M, Jordan P, Krishnan AC, Turner B, Pearson C, Twiner MJ, Levy P (2022) Public housing resident perspectives on smoking cessation, and changes in smoking mandates. Inquiry: The Journal of Health Care Organization 59: 469580221092814.

Greenwald MK, Ghosh S, Winston J (2022) A randomized, sham-controlled, quintuple-blinded trial to evaluate the NET Device as an alternative to medication for promoting opioid abstinence. Contemporary Clinical Trials Communications 30: 101018.

Greenwald MK, Herring AA, Perrone J, Nelson LS, Azar P (2022) A neuropharmacological working model to explain buprenorphine induction challenges. Annals of Emergency Medicine 80: 509-524. DOI: 10.1016/j.annemergmed.2022.05.032

Laffont C, Ngaimisi E, Gopalakrishnan M, Ivaturi V, Young M, Greenwald MK, Heidbreder C (2022) Buprenorphine exposure levels to optimize treatment outcomes in opioid use disorder. Frontiers in Pharmacology 30: 1052113. DOI: 10.3389/fphar.2022.1052113

Lister JJ, Ellis JD, Struble CA, Ledgerwood DM, Greenwald MK (2022) Protective factor predictors of abstinence and retention in patients receiving methadone treatment for opioid use disorder. International Journal of Mental Health and Addiction. DOI: 10.1007/s11469-022-00893-z

Lister JJ, Yoon M, Nower L, Ellis JD, Ledgerwood DM (2022) Subtypes of patients with opioid use disorder in methadone maintenance treatment: a pathways model analysis. International Gambling Studies 22: 300-316.

Moses TEH, Chou JS, Moreno J, Lundahl LH, Waineo E, Greenwald MK (2022) Long-term effects of opioid overdose prevention and response training on medical student knowledge and attitudes toward opioid overdose: a pilot study.  Addictive Behaviors 126: 107172.

Moses TEH, Rhodes GL, Tavakoli E, Christensen C, Amirsadri A, Greenwald MK (2022) Predictors of retention and drug use among patients with opioid use disorder transferred to a specialty ‘Second Chance’ methadone program. Substance Abuse: Research and Treatment 16: 1-11. DOI: 10.1177/11782218221138335

Nagle L, Moses TE, Chitale A, Chou J, Lien I, Waineo E, Greenwald MK (2022) Building a strong foundation from the ground up: the impact of medical student substance use disorder organizations on curriculum and community. Journal of Addictive Diseases. DOI: 10.1080/10550887.2022.2068907

Struble C, Bauer SJ, Lundahl LH, Ghosh S, Ledgerwood DM (2022) Electronic cigarette use among sexual minority and heterosexual young adults in a U.S. national sample: exploring the modifying effects of advertisement exposure. Preventive Medicine 155: 106926. DOI: 10.1016/j.ypmed.2021.106926

Struble C, Lister JJ, Urbiel J, Nyaku AN, Arfken CL (2022) Comparison of injection and non-injection opioid use among black people in methadone treatment: a pilot study. Addictive Behaviors 126: 107182. DOI: 10.1016/j.addbeh.2021.107182

Toloff K, Woodcock EA (2022) Is the neuroimmune system a therapeutic target for opioid use disorder? A systematic review. Medical Research Archives 10: 2955. DOI: 10.18193/mra.v10i8.2955

2021

Bae EH, Greenwald MK, Schwartz AG (2021) Chemotherapy-induced peripheral neuropathy: mechanisms and therapeutic avenues. Neurotherapeutics 18(4): 2384-2396. DOI: 10.1007/s13311-021-01142-2

Carr MM, Ellis JD, Saules KK, Page JL, Staples A, Ledgerwood DM (2021) Substance use, gambling, binge-eating, and hypersexuality symptoms among patients receiving opioid agonist therapies. The American Journal on Addictions 30(4): 343-350.

Edelman EJ, Dziura J, Deng Y, Bold K, Murphy SM, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein S (2021 Nov) A SMARTTT approach to treating tobacco use disorder in persons with HIV (SMARTTT): rationale and design for a hybrid type 1 effectiveness-implementation study. Contemporary Clinical Trials 110: 106379. DOI: 10.1016/j.cct.2021.106379

Ellis JD, Struble C, Fodor M, Cairncross M, Lundahl LH, Ledgerwood DM (2021) Contingency management for individuals with chronic health conditions: a systematic review and meta-analysis of randomized controlled trials. Behavior Research and Therapy, 136: 103781.

Faraj MM, Lipanski NM, Morales A, Goldberg E, Bluth M, Marusak HA, Greenwald MK (2021 May 6) A virtual reality meditative intervention modulates pain and the pain neuromatrix in patients with opioid use disorder. Pain Medicine 22(11): 2739-2753. DOI: 10.1093/pm/pnab162

Greenwald MK, Akcasu N, Baal P, Outlaw AY, Cohn JA, Lundahl LH (2021 Nov 7) Marijuana and complementary/alternative self-treatment approaches for symptom management among African American persons living with HIV. AIDS Care. DOI: 10.1080/09540121.2021.1998311

Greenwald MK, Lundahl LH, Shkokani L, Syed S, Roxas RS, Levy P (2021 Dec 2) Effects of cocaine and/or heroin use history on resting cardiovascular function. International Journal of Cardiology: Cardiovascular Risk and Prevention 11: 200123. PMID: 34927171; DOI: 10.1016/j.ijcrp.2021.200123

Greenwald MK, Moses TEH, Roehrs TA (2021) At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities. Translational Research 234: 58-73. DOI: 10.1016/j.trsl.2021.03.006

Greenwald MK, Sarvapelli S, Lundahl LH, Cohn J (2021) Demand curve analysis of marijuana use among persons living with HIV/AIDS. Drug and Alcohol Dependence 220: 108524. DOI: 10.1016/j.drugalcdep.2021.108524

Hailozian C, Luftig J, Liang A, Outhay M, Ullal M, Anderson ES, Kalmin M, Shoptaw S, Greenwald MK, Herring AA (2021 Nov 16) Synergistic effect of ketamine and buprenorphine observed in the treatment of buprenorphine opioid withdrawal in a fentanyl-using patient. Journal of Addiction Medicine. DOI: 10.1097/ADM.0000000000000929

Isaacs KR, Atreyapuapu S, Alyusuf A, Ledgerwood DM, Finnegan LP, Chang KHK, Ma TX, Washio Y (2021) Neonatal outcomes after combined opioid and nicotine exposure in utero: a scoping review. International Journal of Environmental Research and Public Health 18: 10215. DOI: 10.3390/ijerph181910215

Kamgar M, Greenwald MK, Assad H, Hastert TA, McLaughlin E, Reding K, Paskett ED, Bea JW, Shadyab AH, Neuhouser ML, Nassir R, Crane TE, Sreeram K, Simon MS (2021 July 29) Prevalence and predictors of peripheral neuropathy after breast cancer treatment. Cancer Medicine. DOI: 10.1002/cam4.4202

Karavidha K, Burmeister M, Greenwald MK (2021) Beta-arrestin2 (ARRB2) polymorphism associated with the adverse consequences of chronic heroin use. The American Journal on Addictions 30: 351-357. DOI: 10.1111/ajad.13150

Lundahl LH, Cannoy C (in press) Adolescent substance use during COVID-19. Pediatric Clinics of North America.

Moses TEH, Moreno JL, Greenwald MK, Waineo E (2021) Training medical students in opioid overdose prevention and response: comparison of in-person vs. online formats. Medical Education Online 26(1): 1994906. DOI: 10.1080/10872981.2021.1994906.

Moses TEH, Chammaa M, Ramos R, Waineo E, Greenwald MK (2021) Incoming medical students’ knowledge of and attitudes towards people with substance use disorders: implications for curricular training. Substance Abuse 42: 692-698. DOI: 10.1080/08897077.2020.1843104

Moses TEH†, Moreno JL, Greenwald MK, Waineo E (2021) Training medical students in opioid overdose prevention and response: comparison of in-person vs. online formats. Medical Education Online 26(1): 1994906. DOI: 10.1080/10872981.2021.1994906

Moses TEH, Moreno JL, Greenwald MK, Waineo E (2021 July 2) Developing and validating an opioid overdose prevention and response curriculum for undergraduate medical education. Substance Abuse. DOI: 10.1080/08897077.2021.1941515

Poland CA, Bennett L, Strutz KL, Plantegenest G, Greenwald MK (2021 Oct 19) A novel online curriculum and coaching strategy to expand the addiction medicine workforce: the Michigan Collaborative Addiction Resources and Education System. Academic Medicine. DOI: 10.1097/ACM.0000000000004470

Trendowski MR, Lusk CM, Ruterbusch JJ, Seaton R, Simon MS, Greenwald MK, Harper FWK, Beebe-Dimmer JL, Schwartz AG (2021) Chemotherapy-induced peripheral neuropathy in African American cancer survivors: risk factors and quality of life outcomes. Cancer Medicine 10(22): 8151-8161. DOI: 10.1002/cam4.4328

Wiest K, Shaya G, Somaini L, Greenwald MK (2021 Jan 18) RBP-6000: a rationally designed prolonged-release buprenorphine formulation. Heroin Addiction and Related Clinical Problems 23(5): 23-36.

Woodcock EA, Hillmer AT, Sandiego CM, Maruff P, Carson RE, Cosgrove KP, Pietrzak RH (2021) Acute neuroimmune stimulation impairs verbal memory in adults: a PET brain imaging study. Brain, Behavior and Immunity 91: 784-787.

2020

Arfken CL, Owens DD, Greenwald MK (2020) US national treatment admissions with opioids and benzodiazepines. Drug and Alcohol Review 39: 862-869.

Carr MM, Saules KK, Ellis JD, Staples A, Ledgerwood DM, Loverich T (2020) Development and validation of the Recognizing Addictive Disorders scale: a transdiagnostic measure of substance-related and other addictive disorders. Substance Use & Misuse 55: 2194-2204.

Ellis JD, Struble CA, Fodor MC, Cairncross M, Lundahl LH, Ledgerwood DM (2020) Contingency management for individuals with chronic health conditions: a systematic review and meta-analysis of randomized controlled trials. Behavior Research & Therapy 136: 103781.

Ledgerwood DM (2020) Nancy Petry’s impact on the Gambling Disorder field: mechanisms, treatment and the DSM 5. Psychology of Addictive Behaviors 34: 194-200.

Ledgerwood DM, Dyshniku F, McCarthy J, Ostojic D, Forfitt J, Rumble S (2020) Gambling-related cognitive distortions in residential treatment for gambling disorder. Journal of Gambling Studies 36: 669-683.

Lister JJ, Weaver A, Ellis JD, Himle JA, Ledgerwood DM (2020) A systematic review of rural-specific barriers to medication treatment for opioid use disorder in the United States. American Journal of Drug and Alcohol Abuse 46: 273-288.

Lister JJ, Weaver A, Ellis JD, Ledgerwood DM, Himle JA (2020) Shortages of medication-assisted treatment for opioid use disorder in underserved Michigan counties: examining the influence of urbanicity and income level. Journal of Healthcare for the Poor and Underserved 31: 1291-1307.

Malburg C, Fucinari J, Ruterbusch JJ, Ledgerwood DM, Beebe-Dimmer JL, Schwartz AG, Cote ML (2020) Continued smoking in African American cancer survivors: the Detroit Research Center Survivors cohort. Cancer Medicine 9: 7763-7771.

Moses TEH, Lister JJ, Greenwald MK (2020) A comparison of substance use patterns among lifetime heroin-injecting individuals across racial groups. Addiction Research & Theory 28: 260-268.

Woodcock EA, Lundahl LH, Khatib D, Stanley JA, Greenwald MK (2020) N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals. Addiction Biology e12900. DOI: 10.1111/adb12900

Woodcock EA, Schain M, Cosgrove KP, Hillmer AT (2020) Quantification of [11C]PBR28 data after systemic lipopolysaccharide challenge. EHNMMI Research 10: 19.

Woodcock EA, Stanley JA, Diwadkar VA, Khatib D, Greenwald MK (2020) A neurobiological correlate of stress-induced nicotine-seeking behavior among cigarette smokers. Addiction Biology 25(4): e12819. DOI: 10.1111/adb.12819

Woodcock EA, Zakiniaeiz Y, Morris ED, Cosgrove KP (2020) Sex and the dopaminergic system: insights from addiction studies. Handbook of Clinical Neurology 175: 141-165.

2019

Cairncross M, Milosevic A, Struble CA, Ellis JD, Ledgerwood DM (2019) Clinical and personality characteristics of problem and pathological gamblers with and without symptoms of adult ADHD. Journal of Nervous and Mental Disease 207: 246-254.

Ellis JD, Cairncross M, Struble CA, Carr MM, Ledgerwood DM, Lundahl LH (2019) Correlates of treatment retention and opioid use among postpartum women in methadone treatment. Journal of Addiction Medicine 13: 153-158.

Ellis JD, Carr MM, Ledgerwood DM (2019) Executive function in problem gamblers with and without history of depression. International Journal of Mental Health and Addiction 16: 1085-1094.

Greenwald MK, Ruterbusch JJ, Beebe‐Dimmer JL, Simon MS, Albrecht T, Schwartz AG (2019) Risk of incident claims for chemotherapy-induced peripheral neuropathy among women with breast cancer in a Medicare population. Cancer 125(2): 269-277.

Haight BR, Learned SM, Laffont CM, Fudala PJ, Zhao Y, Garofalo A, Greenwald MK, Nadipelli VR, Ling W, Heidbreder C; for the RBP-6000 13-0001 Study Investigators (2019) Efficacy and safety of a monthly buprenorphine depot injection for opioid use disorder: a multicentre, randomised, double-blind, placebo-controlled trial. The Lancet 393(10173): 778-790.

Herring AA, Schultz CW, Yang E, Greenwald MK (2019) Rapid induction onto sublingual buprenorphine after opioid overdose and successful linkage to treatment for opioid use disorder. The American Journal of Emergency Medicine 37: 2259-2262.

Ledgerwood DM, Cunningham PB (in press) Juvenile drug treatment court. In: Lundahl LH, Rosenberg DR (Eds.), Adolescent Substance Use and Misuse, Pediatric Clinics of North America 66: 1193-1202.

Ledgerwood DM, Dyshniku F, McCarthy J, Ostojic D, Forfitt J, Rumble S (in press) Gambling-related cognitive distortions in residential treatment for gambling disorder. Journal of Gambling Studies.

Ledgerwood DM, Lister JJ, LaLiberte B, Lundahl LH, Greenwald MK (2019) Injection opioid use as a predictor of treatment outcomes among methadone-maintained opioid-dependent patients. Addictive Behaviors 90: 191-195.

Lister JJ, Brown S, Greenwald MK, Ledgerwood DM (2019) Gender-specific predictors of methadone treatment outcomes among African Americans at an urban clinic. Substance Abuse 40: 185-193.

Lundahl LH, Rosenberg DR (Eds.) (2019) Adolescent Substance Use and Misuse. Pediatric Clinics of North America. Philadelphia, PA: Elsevier.

Moses TEH, Burmeister M, Greenwald MK (2019 June 13; Epub ahead of print) Heroin delay discounting and impulsivity: modulation by DRD1 genetic variation. Addiction Biology 25: e12777. PMID: 31192519; DOI: 10.1111/adb.12777 

Moses TEH, Greenwald MK (2019) History of regular nonmedical sedative and/or alcohol use differentiates substance-use patterns and consequences among chronic heroin users. Addictive Behaviors 97: 14-19.

Struble C, Ellis J, Cairncross M, Lister JJ, Lundahl LH (2019) Demographic, cannabis use, and depressive correlates of cannabis use consequences in regular cannabis users. American Journal of Addictions 28: 295-302.

Struble CA, Ellis JD, Lundahl LH (in press) Beyond the bud: emerging methods of cannabis consumption for youth. In: Lundahl LH, Rosenberg DR (Eds.), Adolescent Substance Use and Misuse, Pediatric Clinics of North America 66: 1087-1097.

Williams JF, Lundahl LH (2019) Focus on adolescent use of club drugs and “other” substances. In: Lundahl LH, Rosenberg DR (Eds.), Adolescent Substance Use and Misuse, Pediatric Clinics of North America 66: 1121-1134.

Woodcock EA, Greenwald MK, Khatib D, Diwadkar VA, Stanley JA (2019) Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation. NeuroImage 186: 437-445.

Woodcock EA, Hillmer AT, Mason GF, Cosgrove KP (2019) Imaging biomarkers of the neuroimmune system among substance use disorders: a systematic review. Molecular Neuropsychiatry 5: 125-146.

2018

Carr MM, Ellis JD, Ledgerwood DM (2018) Suicidality among gambling helpline callers: a consideration of the role of financial stress and conflict. American Journal on Addictions 27: 531-537.

Ellis JD, Lister JJ, Struble CA, Cairncross M, Carr MM, Ledgerwood DM (2018) Client and clinician-rated characteristics of problem gamblers with and without history of gambling-related illegal behaviors. Addictive Behaviors 84: 1-6.

Greenwald MK (2018) Anti-stress neuropharmacological mechanisms and targets for addiction treatment: a translational framework.  Neurobiology of Stress 9: 84-104.

Greenwald MK (2018) Opioid substitution treatment and harm minimization approaches. In: Pickard H, Ahmed SH (Eds.), The Routledge Handbook of Philosophy and Science of Addiction, pp. 478-489 (chapter 38). New York: Routledge Press.

Moses TEH, Lundahl LH, Greenwald MK (2018) Factors associated with sedative use and misuse among heroin users. Drug and Alcohol Dependence 185: 10-16. 

Moses TEH, Woodcock EA, Lister JJ, Lundahl LH, Greenwald MK (2018) Developing a scale of domains of negative consequences of chronic heroin use. Addictive Behaviors 77: 260-266.

Reid HH, Lundahl LH, Lister JJ, Woodcock EA, Greenwald MK (2018) Mediational pathways among trait impulsivity, heroin-use consequences, and current mood state. Addiction Research & Theory 26: 421-429.

Williams K, Levine AR, Ledgerwood DM, Amirsadri A, Lundahl LH (2018) Characteristics and triage of children presenting in mental health crisis to emergency departments at Detroit regional hospitals. Pediatric Emergency Care 34(5): 317-321.

2017

Arfken CL, Suchanek J, Greenwald MK. Characterizing fentanyl use in methadone-maintained clients. Journal of Substance Abuse Treatment 75: 17-21. 

Hand DJ, Ellis JD, Carr MM, Abatemarco DJ, Ledgerwood DM (2017) Contingency management interventions for tobacco and other substance use disorders in pregnancy. Psychology of Addictive Behaviors 31: 907-921.

Jackson A, Bagdas D, Muldoon PP, Lichtman AH, Carroll FI, Greenwald MK, Miles MF, Damaj MI. In vivo interactions between the a-7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-a: implication for nicotine dependence. Neuropharmacology 118: 38-45. 

Ledgerwood DM, Arfken CL; Michigan Association on Problem Gambling. Assessing the need for higher levels of care among problem gambling outpatients. Journal of Gambling Studies 33: 1263-1275.

Lister JJ, Greenwald MK, Ledgerwood DM. Psychosocial characteristic predictors of drug use among African-American patients during first-month induction/stabilization on methadone. Journal of Substance Abuse Treatment 78: 15-21.

Lister JJ, Greenwald MK, Ledgerwood DM. Baseline risk factors for drug use among African-American patients during first-month induction/stabilization on methadone.  Journal of Substance Abuse Treatment 78: 15-21. 

Moon M, Lister J, Milosevic A, Ledgerwood DM. Subtyping problem gambling among community-recruited gamblers. Journal of Gambling Studies 33: 841-853.

Moses TE, Woodcock EA, Lister JJ, Lundahl LH, Greenwald MK. Developing a scale of domains of negative consequences of chronic heroin use. Addictive Behaviors 77: 260-266. 

Resko SM, Brown S, Lister, JJ, Ondersma SJ, Cunningham RM, Walton MA. Technology-based interventions and trainings to reduce the escalation and impact of alcohol problems. Journal of Social Work Practice in the Addictions, 17(1-2): 114-134.

Santana TEM, Greenwald MK, Rosen MI (2017) Risk/benefit discussion of alcohol use disorder medications: behavioral economic considerations and general recommendations. Journal of Addiction Research & Therapy 8: 2.

2016

Lundahl LH, Greenwald MK. Magnitude and duration of cue-induced craving for marijuana in volunteers with cannabis use disorderDrug and Alcohol Dependence 166: 143-149. 

Bohnert ASB, Bonar EE, Cunningham R, Greenwald MK, Thomas L, Chermack S, Blow FC, Walton M. A pilot randomized clinical trial of an intervention to reduce overdose risk behaviors among emergency department patients at risk for prescription opioid overdose. Drug and Alcohol Dependence 163: 40-47.

Nasser AF, Greenwald MK, Vince B, Fudala PJ, Twumasi-Ankrah P, Liu Y, Jones JP III, Heidbreder C. Sustained-release buprenorphine (RBP-6000) blocks the effects of opioid challenge with hydromorphone in subjects with opioid use disorder. Journal of Clinical Psychopharmacology 36: 18-26.

Maslowsky J, Schulenberg J, Chiodo LM, Hannigan JH, Greenwald MK, Janisse J, Sokol RJ, Delaney-Black V. Parental support, mental health, and alcohol and marijuana use in national and high-risk African American adolescent samples. Substance Abuse Research and Treatment 9 (Suppl 1): 11-20.

2015

Stoltman JJK, Woodcock EA, Lister JJ, Lundahl LH, Greenwald MK. Heroin delay discounting: modulation by pharmacological state, drug-use impulsivity and intelligence. Experimental and Clinical Psychopharmacology 23: 455-463. 

Greenwald MK, Woodcock EA, Khatib D, Stanley JA. Methadone maintenance dose modulates anterior cingulate glutamate levels in heroin-dependent individuals: a preliminary in vivo 1H MRS study. Psychiatry Research: Neuroimaging 233: 218-224.

Woodcock EA, Lundahl LH, Burmeister M, Greenwald MK. Functional mu opioid receptor polymorphism (OPRM1 A118G) associated with heroin use outcomes in Caucasian males: a pilot study. The American Journal on Addictions 24: 329-335.

Lundahl LH, Greenwald MK. Effect of oral THC pretreatment on marijuana cue-induced responses in cannabis dependent volunteers. Drug and Alcohol Dependence 149: 187-193.

Levine AR, Lundahl LH, Ledgerwood DM, Lisieski M, Rhodes GL, Greenwald MK. Gender-specific predictors of retention and opioid abstinence during methadone maintenance treatment. Journal of Substance Abuse Treatment 54: 37-43.

Woodcock EA, Lundahl LH, Stoltman JJK, Greenwald MK. Progression to regular heroin use: examination of patterns, predictors, and consequences. Addictive Behaviors 45: 287-293.

Stoltman JJK, Woodcock EA, Lister JJ, Greenwald MK, Lundahl LH. Exploration of the telescoping effect among not-in-treatment, intensive heroin-using volunteers. Drug and Alcohol Dependence 148: 217-220. 

Woodcock EA, Lundahl LH, Greenwald MK. Predictors of buprenorphine initial outpatient maintenance and dose taper response among non-treatment-seeking heroin dependent volunteers. Drug and Alcohol Dependence 146: 89-96.

Lister JJ, Ledgerwood DM, Lundahl LH, Greenwald MK. Causal pathways between impulsivity, cocaine use consequences, and depression. Addictive Behaviors 41: 1-6.